Chloramphenicol palmitate may cause interactions when administered alongside drugs like phenobarbital, primidone, tylosin, phenytoin, and cyclophosphamide or with other antibiotics like amoxicillin, clindamycin or erythromycin.

1 although the quinolones have revolutionized the approach to treating severe infections in the outpatient setting, other oral agents such as clindamycin, trimethoprim sulfamethoxazole, metronidazole, doxycycline, and minocycline also offer excellent bioavailability, favorable dosing schedules, good tissue penetration, long-term tolerability, and low cost.