When the family cannot be promptly tested, consideration should be given to the administration of isoniazid 10 mg kg d to the infant until skin testing of the family has excluded contact with a case of active tuberculosis.
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isoniazid and paracetamol are both suggested to be metabolised via cyp 2e1.
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isoniazid is readily absorbed from the gastrointestinal tract and after intramuscular injection.
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serious and sometimes fatal liver problems may occur during treatment with isoniazid or after you stop taking this medication, even months after stopping.
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Preventive therapy generally should be started after delivery to prevent putting the fetus at risk of exposure; the low levels of dom-isoniazid in breast milk do not threaten the neonate.
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