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With careful monitoring and help from a physician, patients can discontinue their use of seroquel safely with few withdrawal symptoms.

Usual dose of seroquel for acute monotherapy or adjunct therapy with lithium or divalproex administer orally once daily in the evening starting with 300 mg on day 1, 600 mg on day 2, and adjust between 400 mg and 800 mg per day thereafter depending on the clinical response and tolerance of the individual patient.

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It is not clear how seroquel makes people gain weight.

Medical experts speculate that seroquel blocks dopamine type 2 receptors and serotonin type 2 receptors in the brain.