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Most often, methotrexate is combined with other dmards, such as leflunomide arava , cyclosporine neoral , sulfasalazine azulfadine and hydroxychloroquine plaquenil .

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Biologics are seen as a significant advancement over other drugs used to treat rheumatoid arthritis for example, methotrexate rheumatrex, trexall, and generic , leflunomide arava and generic , hydroxychloroquine plaquenil and generic , and sulfasalazine azulfidine and generic which are often referred to as conventional or nonbiologic.

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