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in studies in children with acute otitis media, oral cefixime 8 mg kg once daily or 4 mg kg twice daily was as effective as oral amoxicillin 20 or 40 mg kg daily given in 3 equally divided doses , oral amoxicillin and clavulanate potassium 40 mg of amoxicillin per kg daily in 3 equally divided doses , oral cefpodoxime proxetil 10 mg kg once daily , or oral cefaclor 40 mg kg daily given in 3 equally divided doses for the treatment of infections caused by susceptible b-lactamase-producing m.
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with the recent rise in the prevalence of fluoroquinolone resistance in southern africa, there has been a regional move, initiated in south africa 2008 and namibia 2009 , to replace fluoroquinolones with single-dose oral cefixime.
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positive direct antiglobulin coombs test results, neutropenia, pancytopenia, agranulocytosis, aplastic anemia, hemolytic anemia, and hemorrhage have been reported with other cephalosporins but have not been reported to date with cefixime.
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when coinfection with chlamydia is demonstrated or suspected, cefixime could be combined with azithromycin; this or other dual therapies could be useful more generally as well, and future modelling work should consider the evolutionary dynamics of multiple antibiotics concurrently.
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