Therapeutic guidelines recommend carbamazepine as a second-line choice for maintenance treatment of bipolar disorder; 6 8 thus, concomitant use of carbamazepine and olanzapine occurs in clinical practice.
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in addition, concurrent use of olanzapine and tetrabenazine should generally be avoided since the risk of adverse effects such as drowsiness, sedation, dizziness, orthostatic hypotension, neuroleptic malignant syndrome, or extrapyramidal symptoms may be increased.
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the major side effects of olanzapine were sedation and weight gain mean 5 kg , although epss were not observed.
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modest mean increases in total cholesterol have also been seen with olanzapine use.
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in cases of acute agitiation, olanzapine can also be administered by intramuscular injection in doses up to 10 milligrams.
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