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for people who had intolerance to clopidogrel and aspirin, treatment with modified-release dipyridamole alone had an icer of 314 per qaly gained in comparison with no preventive therapy.
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the us food and drug administration recommends that the coadministration of omeprazole and plavix clopidogrel be avoided, based on data showing that the proton pump inhibitor reduces the efficacy of plavix by nearly 50 .
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Esomeprazole reduces the activity of these enzymes and potentially can reduce the activity of clopidogrel.
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