Patients were given oral paroxetine 20 mg daily beginning seven days after the initiation of the first cycle of chemotherapy for newly diagnosed breast cancer and continued until seven days following their fourth cycle of chemotherapy or placebo.
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do not use paroxetine within 14 days before or 14 days after you have used a mao inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
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as a reduced effect of tamoxifen cannot be excluded, co-administration with potent cyp2d6 inhibitors including paroxetine should whenever possible be avoided see section 4.
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