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neratinib is a cyp3a4 substrate and diltiazem is a moderate cyp3a4 inhibitor.
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if these agents are to be administered concurrently, cyclosporine concentrations should be monitored, especially when diltiazem therapy is initiated, adjusted, or discontinued.
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coadministration with a strong cyp3a4 inducer lowered diltiazem plasma concentrations to undetectable levels.
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Diltiazem is a moderate inhibitor of cyp3a4 and may reduce the hepatic metabolism of cyp3a4 substrates, although the impact of moderate cyp3a4 inhibitors on cariprazine metabolism has not been studied.
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