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Therefore, the dosing of intrathecal methotrexate should be based on the age not the body surface area.

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Chloramphenicol minor chloramphenicol may decrease intestinal absorption of methotrexate or interfere with enterohepatic circulation by inhibiting bowel flora and suppressing metabolism of the drug by bacteria.

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Serum chorionic gonadotropin levels should be monitored on days 4 and 7 methotrexate is administered on day 1 .

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seventy-five percent of all cases of severe liver damage reported until early 2001 were seen under combined drug therapy leflunomide plus methotrexate.

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