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indinavir major coadministration with strong cyp3a4 inhibitors such as indinavir is not recommended without adjustments in the dosing regimen of tacrolimus and subsequent close monitoring of tacrolimus whole blood trough concentrations and tacrolimus-associated adverse reactions.
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indinavir is primarily metabolized by the cyp3a4 isoenzyme, and similar to other protease inhibitors, co-administration with low dose ritonavir, a potent cyp3a4 inhibitor, enhances its pharmacokinetic profile allowing less frequent dosing and the removal of food restrictions 6 .
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