Probenecid benemid and cimetidine tagamet, tagamet hb may increase the effects of valtrex and possibly lead to dangerous side effects.
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acyclovir cmax and auc following a single dose of valtrex 1 gram increased by 8 and 32 , respectively, after a single dose of cimetidine 800 mg , or by 22 and 49 , respectively, after probenecid 1 gram , or by 30 and 78 , respectively, after a combination of cimetidine and probenecid, primarily due to a reduction in renal clearance of acyclovir.
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