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While extensive clinical studies evaluating the use of naltrexone hydrochloride in detoxified, formerly opioid-dependent individuals failed to identify any single, serious untoward risk of naltrexone hydrochloride use, placebo-controlled studies employing up to five fold higher doses of naltrexone hydrochloride up to 300 mg per day than that recommended for use in opiate receptor blockade have shown that naltrexone hydrochloride causes hepatocellular injury in a substantial proportion of patients exposed at higher doses see warnings and precautions, laboratory tests .

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counselling sessions, cognitive behavioural therapy and meditation have all proved beneficial to users of naltrexone.

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in blocking the effectiveness of the drug, naltrexone helps to break the cycle of drug use.
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