Amoxicillin; clarithromycin; lansoprazole major use caution when administering high-dose methotrexate to patients receiving proton pump inhibitors ppis ; a temporary withdrawal of the ppi should be considered in some patients receiving high-dose methotrexate.
If you might be pregnant, do not start methotrexate until you know for sure that you are not pregnant.
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Recently, use of methotrexate in combination with anti-tnf agents has been shown to be effective for the treatment of ulcerative colitis.
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methotrexate can cause severe toxicity which usually is related to the dose taken.
