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use of colchicine for treatment of gout flare is not recommended in patients with renal impairment who are receiving the drug for prevention of gout flares.
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when clarithromycin and colchicine are administered together, inhibition of pgp and or cyp3a by clarithromycin may lead to increased exposure to colchicine.
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it possesses an alkaloid, colchicine, which is used in the treatment of arthritis and gout.
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