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According to the latest reports, there is a potential for digoxin-bupropion drug interaction 4.

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a very nice contribution lamenting the fact that digoxin use has diminished dramatically over the last decade, whereas publications about this drug were common a decade ago, few studies of the agent, clinical trials, or use descriptions are currently available.

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only 1 of the total amount of digoxin in the body is in the serum; of that amount, approximately 25 is protein bound.
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Use of digoxin was associated with a trend in reduction in time to all-cause death or hospitalization.

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