Effect of orlistat treatment on body composition and resting energy expenditure during a two-year weight-reduction programme in obese finns.
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In a pharmacokinetic study conducted in healthy volunteers who received 120 mg orlistat three times daily for 13 days and a single dose of 120 mg orlistat on the morning of day 14 co-administered with a single dose of 1200 mg amiodarone on day 4, a 23 27 reduction in the systemic exposure to amiodarone and desethylamiodarone was observed see drug interactions 7.
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Questions remain regarding whether improvements in risk factors may occur in all obese persons or only in high-risk groups, whether orlistat affects general morbidity and mortality in treated populations, and whether weight loss studies are applicable to the everyday clinical management of obese patients.
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